Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Oct 2000

Roth W, Deussing J, Botchkarev V A, Pauly-Evers M, Saftig P, Hafner A, Schmidt P, Schmahl W, Scherer J, Anton-Lamprecht I, Von Figura K, Paus R, Peters C

Abstract excerpt

Lysosomal cysteine proteinases of the papain family are involved in lysosomal bulk proteolysis, major histocompatibility complex class II mediated antigen presentation, prohormone processing, and extracellular matrix remodeling. Cathepsin L (CTSL) is a ubiquitously expressed major representative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alopecia
Share to Cathepsin L

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsins

Share to Epidermis

Share to Hair Follicle

Share to Hyperplasia

Share to Keratosis

Share to Periodicity

Source

Identifiers

PMID: 11023992
DOI: 10.1096/fj.99-0970com

Genes

CTSL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11023992-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.PMID 11023992Read ↗

The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling.Semantic proximity Read ↗

Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.Semantic proximity Read ↗

Secretory phospholipase A2-IIA overexpressing mice exhibit cyclic alopecia mediated through aberrant hair shaft differentiation and impaired wound healing response.Semantic proximity Read ↗

Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilegeSemantic proximity Read ↗

Mutant laboratory mice with abnormalities in hair follicle morphogenesis, cycling, and/or structure: an update.Semantic proximity Read ↗

Regional Control of Hairless versus Hair-Bearing Skin by Dkk2Semantic proximity Read ↗

The molecular basis of congenital atrichia in humans and mice: mutations in the hairless gene.Semantic proximity Read ↗

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair folliclesSemantic proximity Read ↗

Hair follicle disruption facilitates pathogenesis to UVB-induced cutaneous inflammation and basal cell carcinoma development in Ptch(+/-) mice.Semantic proximity Read ↗

The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.Semantic proximity Read ↗

Cathepsin K+ Non-Osteoclast Cells in the Skeletal System: Function, Models, Identity, and Therapeutic ImplicationsSemantic proximity Read ↗

Cathepsin-Mediated Alterations in TGFß-Related Signaling Underlie Disrupted Cartilage and Bone Maturation Associated With Impaired Lysosomal Targeting.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.