Article
Genetic screening for LRRK2 gene G2019S mutation in Parkinson's disease patients from Southern Italy.
Parkinsonism & related disorders - 1 Mar 2009
De Rosa Anna, Criscuolo Chiara, Mancini Pietro, De Martino Marina, Giordano Ilaria Anna, Pappatà Sabina, Filla Alessandro, De Michele Giuseppe
Abstract excerpt
Leuchine-rich repeat kinase 2 (LRRK2) gene mutations are a common cause of familial and sporadic Parkinson disease (PD). G2019S is the most frequent mutation of the LRRK2 gene and has been reported in about 5-6% of familial and 1-2% of sporadic PD cases. The aim of this study is to investigate the G2019S frequency in a series of 58 familial and 70 sporadic PD patients recruited from Campania, a region in Southern...
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