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Article

Posttranscriptional activation of gene expression in <i>Xenopus laevis</i> oocytes by microRNA–protein complexes (microRNPs)

2 May 2011

Abstract excerpt

MicroRNA-protein complexes (microRNPs) can activate translation of target reporters and specific mRNAs in quiescent (i.e., G0) mammalian cell lines. Induced quiescent cells, like folliculated immature oocytes, have high levels of cAMP that activate protein kinase AII (PKAII) to maintain G0 and immature states. We report microRNA-mediated up-regulated expression of reporters in immature Xenopus laevis oocytes,...

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PMID: 21536868
DOI: 10.1073/pnas.1105401108

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