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Article

microRNA 376a regulates follicle assembly by targeting <i>Pcna</i> in fetal and neonatal mouse ovaries

1 Apr 2014

Abstract excerpt

In mammals, the primordial follicle pool, providing all oocytes available to a female throughout her reproductive life, is established perinatally. Dysregulation of primordial follicle assembly results in female reproductive diseases, such as premature ovarian insufficiency and infertility. Female mice lacking Dicer1 (Dicer), a gene required for biogenesis of microRNAs, show abnormal morphology of follicles and...

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PMID: 24686458
DOI: 10.1530/rep-13-0508

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