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Article

Cyclooxygenase-2 gene expression in human breast cancer

1 Mar 1997

Abstract excerpt

Expression of the inducible isoform of the cyclooxygenase gene (PGHS-2, COX-2) which codes for the enzyme that catalyzes formation of prostaglandins, was detected in 13/13 human breast tumors of high grade but not in samples of normal breast tissue. There was a statistically significant linear association between COX-2 gene expression and high (>50%) tumor cell density (p<0.01), with COX-2 protein localized to...

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Identifiers

PMID: 21533404
DOI: 10.3892/ijo.10.3.503

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