The transcriptional mediator component Med12 is required for hindbrain boundary formation.

doi:10.1371/journal.pone.0019076

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Article

The transcriptional mediator component Med12 is required for hindbrain boundary formation.

PloS one - 21 Apr 2011

Hong Sung-Kook, Dawid Igor B

Abstract excerpt

BACKGROUND: Rhombomere boundaries form during hindbrain segmentation and are critical for maintaining segmental integrity and regulating migration in the hindbrain. Some genetic models affecting hindbrain boundary formation have been described, but involvement of components of the transcriptional mediator complex in boundary formation has not reported so far. PRINCIPAL FINDINGS: The kto/med12 mutant zebrafish,...

Topics

Animals
Body Patterning
Cell Proliferation
Mediator Complex
Mutation
Rhombencephalon
Zebrafish
Zebrafish Proteins

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PMID: 21533047
DOI: 10.1371/journal.pone.0019076
PMCID: PMC3080914

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