Article
Prognostic value of the multidrug resistance transporter ABCG2 gene polymorphisms in Chinese patients with de novo acute leukaemia.
European journal of cancer (Oxford, England : 1990) - 1 Sept 2011
Wang Fang, Liang Yong-ju, Wu Xing-ping, Chen Li-ming, To Kenneth Kin Wah, Dai Chun-ling, Yan Yan-yan, Wang Yan-sheng, Tong Xiu-zhen, Fu Li-wu
Abstract excerpt
BACKGROUND: Functional polymorphisms of the ABCG2 gene may contribute to individual variability in drug response and the prognosis of patients. METHODS: In the present study, the genetic polymorphisms and expression of ABCG2 were analysed in blasts cells obtained from 184 Chinese patients with de novo acute leukaemia to investigate their possible association with clinical outcomes. RESULTS: A novel synonymous...
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