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Article

Constitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.

Blood - 23 Jun 2011

Ren MingQiang, Cowell John K

Abstract excerpt

The ZMYM2-FGFR1 (formerly known as ZNF198-FGFR1) fusion kinase induces stem cell leukemia-lymphoma syndrome (SCLL), a hematologic malignancy characterized by rapid transformation to acute myeloid leukemia and T-lymphoblastic lymphoma. In the present study, we demonstrate frequent, constitutive activation of Notch1 and its downstream target genes in T-cell lymphomas that arose in a murine model of ZMYM2-FGFR1...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to Leukemia
Share to Lymphoma, T-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred BALB C

Share to Myeloid Cells

Share to Myeloproliferative Disorders

Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptor, Notch1

Source

Open in PubMed Open full text

Identifiers

PMID: 21527531
DOI: 10.1182/blood-2010-07-295725
PMCID: PMC3128478

Genes

FGFR1
ZMYM2
MAML1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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