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Article

FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome.

Leukemia - 1 Nov 2018

Hu Tianxiang, Wu Qing, Chong Yating, Qin Haiyan, Poole Candace J, van Riggelen Jan, Ren Mingqiang, Cowell John K

Abstract excerpt

Oncogenic transformation of hematopoietic stem cells by chimeric fusion kinases causing constitutive activation of FGFR1 leads to a stem cell leukemia/lymphoma (SCLL) syndrome, accompanied by widespread dysregulation of gene activity. We now show that FGFR1 activation is associated with upregulation of MYC and pharmacological suppression of FGFR1 activation leads to downregulation of MYC and suppression of MYC...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

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Share to Receptor, Fibroblast Growth Factor, Type 1

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Source

Open in PubMed Open full text

Identifiers

PMID: 29720732
DOI: 10.1038/s41375-018-0124-y
PMCID: PMC6168426

Genes

MYC
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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