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Article

Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Nov 2011

Squitieri Ferdinando, Maglione Vittorio, Orobello Sara, Fornai Francesco

Abstract excerpt

Huntington's Disease (HD) is caused by trinucleotide CAG repeat expansion >36 in huntingtin (htt), a protein with several documented functions. The elongated polyglutamine (polyQ) stretch in the N-terminal region of htt leads to dysfunctional and degenerative events in neurons and peripheral tissues. In this study, by extending the analysis to several caspase activities (i.e. caspase 2, 3, 6, 8 and 9), we...

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Identifiers

PMID: 21519949
DOI: 10.1007/s00702-011-0646-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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