Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

21 Apr 2011

Abstract excerpt

Mucosal surfaces constantly encounter microbes. Toll-like receptors (TLRs) mediate recognition of microbial patterns to eliminate pathogens. By contrast, we demonstrate that the prominent gut commensal Bacteroides fragilis activates the TLR pathway to establish host-microbial symbiosis. TLR2 on CD4(+) T cells is required for B. fragilis colonization of a unique mucosal niche in mice during homeostasis. A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Identification and Susceptibility Testing
Share to Clostridium difficile and Clostridium perfringens research
Share to Gut microbiota and health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21512004
DOI: 10.1126/science.1206095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human MicrobiotaPMID 21512004Read ↗

Symbionts exploit complex signaling to educate the immune systemSemantic proximity Read ↗

Regulation of surface architecture by symbiotic bacteria mediates host colonization.Semantic proximity Read ↗

Human Gut Commensal Bacteroides fragilis Suppresses Mucin Production and Alters Microbiota Composition Resulting in Accelerated Type 1 Diabetes in MiceSemantic proximity Read ↗

Mucosal interplay among commensal and pathogenic bacteria: Lessons from flagellin and Toll‐like receptor 5Semantic proximity Read ↗

Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activationSemantic proximity Read ↗

The yin yang of bacterial polysaccharides: lessons learned from B. fragilis PSASemantic proximity Read ↗

<i>Bacteroidales</i> Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition <i>In Vivo</i>Semantic proximity Read ↗

A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis.Semantic proximity Read ↗

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunitySemantic proximity Read ↗

An antimicrobial protein of the gut symbiont B acteroides fragilis with a MACPF domain of host immune proteinsSemantic proximity Read ↗

Homeostatic IL-23 receptor signaling limits Th17 response through IL-22–mediated containment of commensal microbiotaSemantic proximity Read ↗

Gut colonization by <i>Bacteroides fragilis</i> at juvenile age alters microbiota composition and accelerates type 1 diabetes progression in non-obese diabetic miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.