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Article

A role for TLR1, TLR2 and NOD2 in cytokine induction by Bacteroides fragilis.

Cytokine - 1 Dec 2012

Stappers Mark H T, Janssen Nico A F, Oosting Marije, Plantinga Theo S, Arvis Pierre, Mouton Johan W, Joosten Leo A B, Netea Mihai G, Gyssens Inge C

Abstract excerpt

Bacteroides fragilis, an intestinal flora commensal microorganism, is frequently isolated from abscesses and soft tissue infections. This study aimed to identify pattern recognition receptors (PRRs) involved in B. fragilis recognition and to characterize the induced cytokine profile. Human PBMCs were stimulated with heat-killed B. fragilis and cytokine levels were determined by ELISA. Roles of individual PRRs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22998942
DOI: 10.1016/j.cyto.2012.08.019

Genes

TLR2
NOD2
TLR1
TLR4
NOD1
TLR6
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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