Article
Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation.
The Biochemical journal - 15 Oct 2002
Li Yuxin, Zhang He, Xie Mingxing, Hu Maowen, Ge Shujun, Yang Dongfang, Wan Yinsheng, Yan Bingfang
Abstract excerpt
The basic helix-loop-helix (bHLH) proteins are intimately associated with developmental events such as cell differentiation and lineage commitment. The HLH domain in the bHLH motif is responsible for dimerization, whereas the basic region mediates DNA binding. Based on sequence alignment and domain analysis, differentially expressed in chondrocytes/stimulated with retinoic acid/split and hairy-related proteins...
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