Article

<i>Nr5a1</i> suppression during the fetal period optimizes ovarian development by fine-tuning of Notch signaling

2018-05-25

Abstract excerpt

<h4>ABSTRACT</h4> The nuclear receptor NR5A1 (also known as Ad4BP, or SF1) is essential for the initial steps of mammalian gonadal development. The Nr5a1 gene is equally expressed in XX and XY gonadal primordia, but after sex determination, is up-regulated in XY and down-regulated in XX gonads. We recently reported a case of 46, XX disorder of sex development (DSD) in which ectopically expressed NR5A1 in XX gonad...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40681c54-0371-5d25-bb58-613cb1be4c76
DOI: 10.1101/331090

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>Nr5a1</i> suppression during the fetal period optimizes ovarian development by fine-tuning of Notch signalingDOI 10.1101/331090Read

Nuclear Receptor Gene Variants Underlying Disorders/Differences of Sex Development through Abnormal Testicular Development.Semantic proximity Read

NR5A1gene variants repress the ovarian-specific WNT signaling pathway in 46,XX disorders of sex development patientsSemantic proximity Read

Steroidogenic Factor 1 Differentially Regulates Fetal and Adult Leydig Cell Development in Male Mice1Semantic proximity Read

NR5A1/SF-1 and development and function of the ovary.Semantic proximity Read

Multifunctional role of steroidogenic factor 1 and disorders of sex development.Semantic proximity Read

Steroidogenic factor-1 (SF-1, NR5A1) and human disease.Semantic proximity Read

Role of NR5A1 Gene Mutations in Disorders of Sex Development: Molecular and Clinical FeaturesSemantic proximity Read

Steroidogenic factor-1 (SF-1, Ad4BP, NR5A1) and disorders of testis development.Semantic proximity Read

A recurrent p.Arg92Trp variant in steroidogenic factor-1 (NR5A1) can act as a molecular switch in human sex developmentSemantic proximity Read

Update--steroidogenic factor 1 (SF-1, NR5A1).Semantic proximity Read

Sex Reversal in a 47,XXY Patient due to a Novel Mutation of NR5A1 Gene: A Case ReportSemantic proximity Read

NR2F2 is required in the embryonic testis for Fetal Leydig Cell developmentSemantic proximity Read