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Article

Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.

Hepatology (Baltimore, Md.) - 1 Nov 2013

Xie Guanhua, Karaca Gamze, Swiderska-Syn Marzena, Michelotti Gregory A, Krüger Leandi, Chen Yuping, Premont Richard T, Choi Steve S, Diehl Anna Mae

Abstract excerpt

UNLABELLED: Liver repair involves phenotypic changes in hepatic stellate cells (HSCs) and reactivation of morphogenic signaling pathways that modulate epithelial-to-mesenchymal/mesenchymal-to-epithelial transitions, such as Notch and Hedgehog (Hh). Hh stimulates HSCs to become myofibroblasts (MFs). Recent lineage tracing studies in adult mice with injured livers showed that some MFs became multipotent progenitors...

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Identifiers

PMID: 23703657
DOI: 10.1002/hep.26511
PMCID: PMC3758784

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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