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Article

Muscular atrophy of caveolin-3-deficient mice is rescued by myostatin inhibition.

The Journal of clinical investigation - 1 Nov 2006

Ohsawa Yutaka, Hagiwara Hiroki, Nakatani Masashi, Yasue Akihiro, Moriyama Keiji, Murakami Tatsufumi, Tsuchida Kunihiro, Noji Sumihare, Sunada Yoshihide

Abstract excerpt

Caveolin-3, the muscle-specific isoform of caveolins, plays important roles in signal transduction. Dominant-negative mutations of the caveolin-3 gene cause autosomal dominant limb-girdle muscular dystrophy 1C (LGMD1C) with loss of caveolin-3. However, identification of the precise molecular mechanism leading to muscular atrophy in caveolin-3-deficient muscle has remained elusive. Myostatin, a member of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17039257
DOI: 10.1172/JCI28520
PMCID: PMC1592547

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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