Article
Altered expression of autoimmune regulator in infant down syndrome thymus, a possible contributor to an autoimmune phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 1 Sept 2014
Skogberg Gabriel, Lundberg Vanja, Lindgren Susanne, Gudmundsdottir Judith, Sandström Kerstin, Kämpe Olle, Annerén Göran, Gustafsson Jan, Sunnegårdh Jan, van der Post Sjoerd, Telemo Esbjörn, Berglund Martin, Ekwall Olov
Abstract excerpt
Down syndrome (DS), caused by trisomy of chromosome 21, is associated with immunological dysfunctions such as increased frequency of infections and autoimmune diseases. Patients with DS share clinical features, such as autoimmune manifestations and specific autoantibodies, with patients affected by autoimmune polyendocrine syndrome type 1. Autoimmune polyendocrine syndrome type 1 is caused by mutations in the...
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