Article
Associations of nicotine intake measures with CHRN genes in Finnish smokers.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Aug 2011
Keskitalo-Vuokko Kaisu, Pitkäniemi Janne, Broms Ulla, Heliövaara Markku, Aromaa Arpo, Perola Markus, Ripatti Samuli, Salminen Outi, Salomaa Veikko, Loukola Anu, Kaprio Jaakko
Abstract excerpt
INTRODUCTION: Genetic effects contribute to individual differences in smoking behavior. Persistence to smoke despite known harmful health effects is mostly driven by nicotine addiction. As the physiological effects of nicotine are mediated by nicotinic acetylcholine receptors (nAChRs), we aimed at examining whether single nucleotide polymorphisms (SNPs) residing in nAChR subunit (CHRN) genes, other than...
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