Article
PathScan: a tool for discerning mutational significance in groups of putative cancer genes.
Bioinformatics (Oxford, England) - 15 Jun 2011
Wendl Michael C, Wallis John W, Lin Ling, Kandoth Cyriac, Mardis Elaine R, Wilson Richard K, Ding Li
Abstract excerpt
MOTIVATION: The expansion of cancer genome sequencing continues to stimulate development of analytical tools for inferring relationships between somatic changes and tumor development. Pathway associations are especially consequential, but existing algorithms are demonstrably inadequate. METHODS: Here, we propose the PathScan significance test for the scenario where pathway mutations collectively contribute to...
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