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Article

Serotonin transporter gene (5HTT) polymorphisms and temporal lobe epilepsy.

Epilepsy research - 1 Jun 2011

Schenkel Laila Cigana, Bragatti José Augusto, Torres Carolina Machado, Martin Kelin Cristine, Gus-Manfro Gisele, Leistner-Segal Sandra, Bianchin Marino Muxfeldt

Abstract excerpt

OBJECTIVE: Preclinical and clinical studies have shown that serotonin levels might modulate susceptibility to seizures. Here we evaluated an association between 5HTTLPR and 5HTTVNTR allele variants in serotonin transporter gene and epileptogenesis in temporal lobe epilepsy (TLE). METHODS: A case-control candidate gene study evaluating the frequencies of 5HTTLPR biallelic and 5HTTVNTR allele variants in patients...

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Source

Identifiers

PMID: 21498047
DOI: 10.1016/j.eplepsyres.2011.03.013

Genes

HTT

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