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Article

Identification of survival motor neuron as a transcriptional activator-binding protein

1 Jul 1999

Abstract excerpt

Spinal muscular atrophy (SMA) is an inherited neuro-muscular disease characterized by specific degeneration of spinal cord anterior horn cells and subsequent muscle atrophy. Survival motor neuron ( SMN ), located on chromosome 5q13, is the SMA-determining gene. In the nucleus, SMN is present in large foci called gems, the function of which is not yet known, while cytoplasmic SMN has been implicated in snRNP...

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Identifiers

PMID: 10369867
DOI: 10.1093/hmg/8.7.1219

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of survival motor neuron as a transcriptional activator-binding proteinPMID 10369867Read ↗

Survival motor neuron (SMN) protein interacts with transcription corepressor mSin3A.Semantic proximity Read ↗

A high-throughput genome-wide RNAi screen identifies modifiers of survival motor neuron proteinSemantic proximity Read ↗

Development of a Gene Therapy Strategy for the Restoration of Survival Motor Neuron Protein Expression: Implications for Spinal Muscular Atrophy TherapySemantic proximity Read ↗

The survival motor neuron protein in spinal muscular atrophySemantic proximity Read ↗

Analysis of mutations in the tudor domain of the survival motor neuron protein SMN.Semantic proximity Read ↗

Gemin5 Binds to the Survival Motor Neuron mRNA to Regulate SMN ExpressionSemantic proximity Read ↗

A Comprehensive Interaction Map of the Human Survival of Motor Neuron (SMN) ComplexSemantic proximity Read ↗

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron proteinSemantic proximity Read ↗

Gemin8 Is a Novel Component of the Survival Motor Neuron Complex and Functions in Small Nuclear Ribonucleoprotein AssemblySemantic proximity Read ↗

Gemins modulate the expression and activity of the SMN complexSemantic proximity Read ↗

Genetic circuitry of Survival motor neuron, the gene underlying spinal muscular atrophy.Semantic proximity Read ↗

HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects.Semantic proximity Read ↗

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