Article
Increased expression level of the splicing variant of SIP1 in motor neuron diseases.
The international journal of biochemistry & cell biology - 1 Jun 2002
Aerbajinai Wulin, Ishihara Tadayuki, Arahata Kiichi, Tsukahara Toshifumi
Abstract excerpt
Survival motor neuron (SMN) interacting protein 1 (SIP1) interacts with SMN protein and plays a crucial role in the biogenesis of spliceosomes. We have identified three novel splicing variants of the SIP1 (SIP1-beta, -gamma and -delta), in addition to the full-length SIP1-alpha. SIP1-alpha as found to be ubiquitously expressed at high levels in the various normal tissues examined. In contrast, SIP1-beta and...
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