Article
Genetic analysis of the neurosteroid deoxycorticosterone and its relation to alcohol phenotypes: identification of QTLs and downstream gene regulation.
PloS one - 8 Apr 2011
Porcu Patrizia, O'Buckley Todd K, Song Soomin C, Harenza Jo Lynne, Lu Lu, Wang Xusheng, Williams Robert W, Miles Michael F, Morrow A Leslie
Abstract excerpt
BACKGROUND: Deoxycorticosterone (DOC) is an endogenous neurosteroid found in brain and serum, precursor of the GABAergic neuroactive steroid (3α,5α)-3,21-dihydroxypregnan-20-one (tetrahydrodeoxycorticosterone, THDOC) and the glucocorticoid corticosterone. These steroids are elevated following stress or ethanol administration, contribute to ethanol sensitivity, and their elevation is blunted in ethanol dependence....
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