Article
Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor.
The Journal of biological chemistry - 20 Feb 2004
Wang Yong, Coulombe René, Cameron Dale R, Thauvette Louise, Massariol Marie-Josée, Amon Lynn M, Fink Dominique, Titolo Steve, Welchner Ewald, Yoakim Christiane, Archambault Jacques, White Peter W
Abstract excerpt
Interaction between the E2 protein and E1 helicase of human papillomaviruses (HPVs) is essential for the initiation of viral DNA replication. We recently described a series of small molecules that bind to the N-terminal transactivation domain (TAD) of HPV type 11 E2 and inhibits its interaction with E1 in vitro and in cellular assays. Here we report the crystal structures of both the HPV11 TAD and of a complex...
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