Article
Crystal structure of the E2 transactivation domain of human papillomavirus type 11 bound to a protein interaction inhibitor.
The Journal of biological chemistry - 20 Feb 2004
Wang Yong, Coulombe René, Cameron Dale R, Thauvette Louise, Massariol Marie-Josée, Amon Lynn M, Fink Dominique, Titolo Steve, Welchner Ewald, Yoakim Christiane, Archambault Jacques, White Peter W
Abstract excerpt
Interaction between the E2 protein and E1 helicase of human papillomaviruses (HPVs) is essential for the initiation of viral DNA replication. We recently described a series of small molecules that bind to the N-terminal transactivation domain (TAD) of HPV type 11 E2 and inhibits its interaction w...
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