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Article

Ulcerative colitis: immune function, tissue fibrosis and current therapeutic considerations.

Langenbeck's archives of surgery - 1 Jan 2012

Maul Jochen, Zeitz Martin

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) is a complex disease in which the interaction of genetic, environmental and microbial factors drives chronic intestinal inflammation that finally leads to extensive tissue fibrosis. DISCUSSION: The present review discusses the current knowledge on genetic susceptibility, especially of the IL-12/IL-23 pathway, the pathophysiologic role of the involved cytokines (e.g. IL-13,...

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Identifiers

PMID: 21479621
DOI: 10.1007/s00423-011-0789-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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