Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus.

Journal of bacteriology - 1 Jun 2011

Zielinska Agnieszka K, Beenken Karen E, Joo Hwang-Soo, Mrak Lara N, Griffin Linda M, Luong Thanh T, Lee Chia Y, Otto Michael, Shaw Lindsey N, Smeltzer Mark S

Abstract excerpt

We demonstrate that mutation of the staphylococcal accessory regulator (sarA) limits the accumulation of alpha-toxin and phenol-soluble modulins (PSMs) in Staphylococcus aureus isolates of the USA300 clonal lineage. Degradation assays and experiments done with protease inhibitors suggested that this was due to the increased production of extracellular proteases rather than differences associated with the impact...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Proteins
Share to Bacterial Toxins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Bacterial

Share to Hemolysin Proteins

Share to Phenols

Share to RNA, Bacterial

Share to RNA, Messenger

Share to Staphylococcus aureus

Source

Open in PubMed Open full text

Identifiers

PMID: 21478342
DOI: 10.1128/JB.01517-10
PMCID: PMC3133183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus.PMID 21478342Read ↗

Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus.Semantic proximity Read ↗

Strain-Dependent Differences in the Regulatory Roles of sarA and agr in Staphylococcus aureusSemantic proximity Read ↗

saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus.Semantic proximity Read ↗

Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation.Semantic proximity Read ↗

SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of Staphylococcus aureus LAC and UAMS-1.Semantic proximity Read ↗

Therapeutic Targeting of the Staphylococcus aureus Accessory Gene Regulator (agr) SystemSemantic proximity Read ↗

The Impacts of msaABCR on sarA-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus.Semantic proximity Read ↗

Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of Staphylococcus aureus sarA mutants in osteomyelitisSemantic proximity Read ↗

Role of SarA in Staphylococcus aureus: A Virulence Target For Therapeutic StrategiesSemantic proximity Read ↗

Staphylococcal accessory regulator (sar) in conjunction with agr contributes to Staphylococcus aureus virulence in endophthalmitis.Semantic proximity Read ↗

Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.Semantic proximity Read ↗

Phenotypic characterization of sarR mutant in Staphylococcus aureus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.