Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.

Clinical genetics - 1 Nov 2015

Steffann J, Monnot S, Bonnefont J-P

Abstract excerpt

Mitochondria are the largest generator of ATP in the cell. It is therefore expected that energy-requiring processes such as oocyte maturation, early embryonic or fetal development, would be adversely impacted in case of mitochondrial deficiency. Human mitochondrial DNA (mtDNA) mutations constitute a spontaneous model of mitochondrial failure and offer the opportunity to study the consequences of energetic defects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blastocyst
Share to DNA, Mitochondrial
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Development

Share to Mutation

Source

Identifiers

PMID: 25523230
DOI: 10.1111/cge.12557

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

mtDNA mutations variously impact mtDNA maintenance throughout the human embryofetal development.PMID 25523230Read ↗

The Role of Mitochondria in Human Fertility and Early Embryo Development: What Can We Learn for Clinical Application of Assessing and Improving Mitochondrial DNA?Semantic proximity Read ↗

Mitochondria and Their Role in Human ReproductionSemantic proximity Read ↗

The Role of Mitochondria in Oocyte and Early Embryo HealthSemantic proximity Read ↗

Effects of adverse fertility-related factors on mitochondrial DNA in the oocyte: a comprehensive reviewSemantic proximity Read ↗

Mitochondrial function in the human oocyte and embryo and their role in developmental competenceSemantic proximity Read ↗

Mitochondria in Human Fertility and InfertilitySemantic proximity Read ↗

Mitochondrial DNA in the oocyte and the developing embryo.Semantic proximity Read ↗

The Importance of Mitochondrial Processes in the Maturation and Acquisition of Competences of Oocytes and Embryo CultureSemantic proximity Read ↗

Mutation dependance of the mitochondrial DNA copy number in the first stages of human embryogenesis.Semantic proximity Read ↗

DOHaD: A Menagerie of Adaptations and Perspectives: The interplay between early embryo metabolism and mitoepigenetic programming of developmentSemantic proximity Read ↗

Mitochondrial replacement therapy and assisted reproductive technology: A paradigm shift toward treatment of genetic diseases in gametes or in early embryosSemantic proximity Read ↗

Mitochondria in early development: linking the microenvironment, metabolism and the epigenomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.