Article
The influence of SaeRS and σ(B) on the expression of superantigens in different Staphylococcus aureus isolates.
International journal of medical microbiology : IJMM - 1 Aug 2011
Kusch Kathrin, Hanke Kirsten, Holtfreter Silva, Schmudde Mareike, Kohler Christian, Erck Christian, Wehland Jürgen, Hecker Michael, Ohlsen Knut, Bröker Barbara, Engelmann Susanne
Abstract excerpt
Staphylococcus aureus is a major human pathogen. Superantigens (SAg) are important virulence factors in S. aureus, but the regulation of SAg gene expression is largely unknown. Using 2 sequenced S. aureus strains (COL and Newman) and 4 clinical isolates, regulation of gene expression was investigated in more detail for 12 SAgs. The SAg-encoding genes were expressed in a growth phase-dependent manner: while the...
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