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Article

The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.

Tissue antigens - 1 May 2006

Fedetz M, Matesanz F, Caro-Maldonado A, Smirnov I I, Chvorostinka V N, Moiseenko T A, Alcina A

Abstract excerpt

The 1858T variant of the protein tyrosine phosphatase gene, PTPN22, is associated with an increased risk of several autoimmune diseases. The aim of this study has been to investigate the possible association of 1858C-->T PTPN22 polymorphism and type 1 diabetes (T1D) in Caucasians from Ukraine. Overall, the distribution of 1858 PTPN22 genotypes differed significantly between the T1D patient group (n = 296) and the...

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Source

Identifiers

PMID: 16671953
DOI: 10.1111/j.1399-0039.2006.00591.x

Genes

PTPN22

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The 1858T PTPN22 gene variant contributes to a genetic risk of type 1 diabetes in a Ukrainian population.PMID 16671953Read ↗

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PTPN22 gene polymorphism (C1858T) is associated with susceptibility to type 1 diabetes: a meta-analysis of 19,495 cases and 25,341 controls.Semantic proximity Read ↗

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Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population.Semantic proximity Read ↗

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