Article
Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients.
Critical care (London, England) - 1 Jan 2011
Koch Alexander, Hamann Lutz, Schott Matthias, Boehm Olaf, Grotemeyer Dirk, Kurt Muhammed, Schwenke Carsten, Schumann Ralf R, Bornstein Stefan R, Zacharowski Kai
Abstract excerpt
INTRODUCTION: Systemic inflammation (for example, following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs) on perioperative adrenocorticotropic hormone (ACTH) and cortisol regulation in serum of cardiac surgical patients. To investigate the link to systemic...
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