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Article

Molecular Defect of the Band 3 Protein in Southeast Asian Ovalocytosis

29 Nov 1990

Abstract excerpt

BACKGROUND: Southeast Asian ovalocytosis is a form of hereditary elliptocytosis in which the red cells are rigid and resistant to malaria invasion. The underlying molecular defect is unknown. METHODS AND RESULTS: We studied the red cells of 54 patients with ovalocytosis and 122 normal controls. We found that ovalocytes contain a structurally and functionally abnormal band 3 protein, the principal transmembrane...

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Identifiers

PMID: 2146504
DOI: 10.1056/nejm199011293232205

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Molecular Defect of the Band 3 Protein in Southeast Asian OvalocytosisPMID 2146504Read ↗

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