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Article

Molecular basis for membrane rigidity of hereditary ovalocytosis. A novel mechanism involving the cytoplasmic domain of band 3.

The Journal of clinical investigation - 1 Feb 1992

Mohandas N, Winardi R, Knowles D, Leung A, Parra M, George E, Conboy J, Chasis J

Abstract excerpt

Hereditary ovalocytic red cells are characterized by a marked increase in membrane rigidity and resistance to invasion by malarial parasites. The underlying molecular defect in ovalocytes remained a mystery until Liu and colleagues (N. Engl. J. Med. 1990. 323:1530-38) made the surprising observation that the ovalocytic phenotype was linked to a structural polymorphism in band 3, the anion transporter. We have now...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 1737855
DOI: 10.1172/JCI115636
PMCID: PMC442903

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Molecular basis for membrane rigidity of hereditary ovalocytosis. A novel mechanism involving the cytoplasmic domain of band 3.PMID 1737855Read ↗

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Band 3 and its alterations in health and disease.Semantic proximity Read ↗

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Aggregation of band 3 in hereditary ovalocytic red blood cell membranes. Electron microscopy and protein rotational diffusion studies.Semantic proximity Read ↗

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