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Article

Molecular basis for membrane rigidity of hereditary ovalocytosis. A novel mechanism involving the cytoplasmic domain of band 3.

The Journal of clinical investigation - 1 Feb 1992

Mohandas N, Winardi R, Knowles D, Leung A, Parra M, George E, Conboy J, Chasis J

Abstract excerpt

Hereditary ovalocytic red cells are characterized by a marked increase in membrane rigidity and resistance to invasion by malarial parasites. The underlying molecular defect in ovalocytes remained a mystery until Liu and colleagues (N. Engl. J. Med. 1990. 323:1530-38) made the surprising observat...

Topics

Amino Acid Sequence
Anion Exchange Protein 1, Erythrocyte
Base Sequence
DNA
Elliptocytosis, Hereditary
Erythrocyte Membrane
Humans
Molecular Sequence Data
Mutation
Protein Conformation

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Identifiers

PMID: 1737855
DOI: 10.1172/JCI115636
PMCID: PMC442903

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1737855-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Molecular basis for membrane rigidity of hereditary ovalocytosis. A novel mechanism involving the cytoplasmic domain of band 3.PMID 1737855Read ↗

Molecular Defect of the Band 3 Protein in Southeast Asian OvalocytosisSemantic proximity Read ↗

Defective anion transport activity of the abnormal band 3 in hereditary ovalocytic red blood cells.Semantic proximity Read ↗

The structure and function of band 3 (AE1): Recent developments (Review)Semantic proximity Read ↗

Analysis of integral membrane protein contributions to the deformability and stability of the human erythrocyte membrane.Semantic proximity Read ↗

The N-terminal 11 amino acids of human erythrocyte band 3 are critical for aldolase binding and protein phosphorylation: implications for band 3 function.Semantic proximity Read ↗

Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton.Semantic proximity Read ↗

Band 3 and its alterations in health and disease.Semantic proximity Read ↗

Structure-function relationships of band 3 variants.Semantic proximity Read ↗

Aggregation of band 3 in hereditary ovalocytic red blood cell membranes. Electron microscopy and protein rotational diffusion studies.Semantic proximity Read ↗

Increased rotational mobility and extractability of band 3 from protein 4.2-deficient erythrocyte membranes: evidence of a role for protein 4.2 in strengthening the band 3-cytoskeleton linkage.Semantic proximity Read ↗

The cytoskeletal binding domain of band 3 is required for multiprotein complex formation and retention during erythropoiesis.Semantic proximity Read ↗

Band 3 Tuscaloosa: Pro327----Arg327 substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2.Semantic proximity Read ↗

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