Article
The pathoetiology of neurofibromatosis 1.
The American journal of pathology - 1 May 2011
Jouhilahti Eeva-Mari, Peltonen Sirkku, Heape Anthony M, Peltonen Juha
Abstract excerpt
Although a mutation in the NF1 gene is the only factor required to initiate the neurocutaneous-skeletal neurofibromatosis 1 (NF1) syndrome, the pathoetiology of the multiple manifestations of this disease in different organ systems seems increasingly complex. The wide spectrum of different clinical phenotypes and their development, severity, and prognosis seem to result from the cross talk between numerous cell...
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