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Preliminary analysis of gene expression profiles in HepG2 cell line induced by different genotype core proteins of HCV.

Cellular & molecular immunology - 1 Jun 2006

Dou Jun, Liu Pengbo, Wang Jing, Zhang Xinjian

Abstract excerpt

In present investigation, we constructed recombinants expressing the HCV genotypes 1b, 2a, and 4d core proteins, and established human hepatocellular carcinoma (HepG2) cell line that expressed various genotype core proteins. The gene expression profiles in the cells expressing different HCV genotype core proteins were compared with those in the control by microarray analysis. In data analysis, a threshold was set...

Topics

Blotting, Western
Carcinoma, Hepatocellular
Cell Line, Tumor
Clone Cells
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genetic Vectors
Genotype
Hepacivirus
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plasmids

Viral Core Proteins

Source

Identifiers

PMID: 16893504

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