Article
Differentially expressed microRNAs in Huh-7 cells expressing HCV core genotypes 3a or 1b: potential functions and downstream pathways.
International journal of molecular medicine - 1 Aug 2012
Gu Yu, Xu Yuqiao, Jiang Lina, Cao Xiangmei, Liu Fang, Li Hang, Zhang Liying, Li Zengshan, Li Jing, Ye Jing, Li Qing
Abstract excerpt
microRNA (miRNA) dysfunction is believed to play important roles in human diseases, including viral infectious diseases. Hepatitis C virus (HCV) infection promotes the development of steatosis, cirrhosis and hepatocellular carcinoma, which is genotype-specific. In order to characterize the miRNA expression profile of Huh-7 cells expressing the HCV core 3a vs. 1b, microarrays and real-time PCR were performed....
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