Article
Variants in the CYP2B6 3'UTR Alter In Vitro and In Vivo CYP2B6 Activity: Potential Role of MicroRNAs.
Clinical pharmacology and therapeutics - 1 Jul 2018
Burgess Kimberly S, Ipe Joseph, Swart Marelize, Metzger Ingrid F, Lu Jessica, Gufford Brandon T, Thong Nancy, Desta Zeruesenay, Gaedigk Roger, Pearce Robin E, Gaedigk Andrea, Liu Yunlong, Skaar Todd C
Abstract excerpt
CYP2B6*6 and CYP2B6*18 are the most clinically important variants causing reduced CYP2B6 protein expression and activity. However, these variants do not account for all variability in CYP2B6 activity. Emerging evidence has shown that genetic variants in the 3'UTR may explain variable drug response by altering microRNA regulation. Five 3'UTR variants were associated with significantly altered efavirenz AUC0-48...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.