Article
Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans.
PLoS genetics - 1 Mar 2011
Murphy John T, Bruinsma Janelle J, Schneider Daniel L, Collier Sara, Guthrie James, Chinwalla Asif, Robertson J David, Mardis Elaine R, Kornfeld Kerry
Abstract excerpt
Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants that were resistant to zinc toxicity. Here we demonstrate that mutations of the C. elegans...
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