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Article

Cellular and viral factors regulating Merkel cell polyomavirus replication.

PloS one - 1 Jan 2011

Feng Huichen, Kwun Hyun Jin, Liu Xi, Gjoerup Ole, Stolz Donna B, Chang Yuan, Moore Patrick S

Abstract excerpt

Merkel cell polyomavirus (MCV), a previously unrecognized component of the human viral skin flora, was discovered as a mutated and clonally-integrated virus inserted into Merkel cell carcinoma (MCC) genomes. We reconstructed a replicating MCV clone (MCV-HF), and then mutated viral sites required for replication or interaction with cellular proteins to examine replication efficiency and viral gene expression....

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Identifiers

PMID: 21799863
DOI: 10.1371/journal.pone.0022468
PMCID: PMC3142164

Genes

MCC

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