Article
Yeast prion protein New1 can break Sup35 amyloid fibrils into fragments in an ATP-dependent manner.
Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2011
Inoue Yuji, Kawai-Noma Shigeko, Koike-Takeshita Ayumi, Taguchi Hideki, Yoshida Masasuke
Abstract excerpt
We report a new type of interaction between two yeast prion proteins, Sup35 and New1. New1 consists of an N-terminal prion region (New1N) and a C-terminal region homologous to a translation elongation factor with two ATP-binding motifs. Amyloid formation of the Sup35 prion region (Sup35NM) was accelerated by a small amount of sonicated New1N amyloid (New1N-seeds) to produce Sup35NM[New1] amyloid. New1N amyloid...
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