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Article

Extra N-terminal residues have a profound effect on the aggregation properties of the potential yeast prion protein Mca1.

PloS one - 29 Mar 2010

Erhardt Marc, Wegrzyn Renee D, Deuerling Elke

Abstract excerpt

The metacaspase Mca1 from Saccharomyces cerevisiae displays a Q/N-rich region at its N-terminus reminiscent of yeast prion proteins. In this study, we show that the ability of Mca1 to form insoluble aggregates is modulated by a peptide stretch preceding its putative prion-forming domain. Based on...

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Identifiers

PMID: 20360952
DOI: 10.1371/journal.pone.0009929
PMCID: PMC2847904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20360952-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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