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Article

Single nucleotide polymorphism arrays: a decade of biological, computational and technological advances.

Nucleic acids research - 1 Jul 2009

LaFramboise Thomas

Abstract excerpt

Array manufacturers originally designed single nucleotide polymorphism (SNP) arrays to genotype human DNA at thousands of SNPs across the genome simultaneously. In the decade since their initial development, the platform's applications have expanded to include the detection and characterization of copy number variation--whether somatic, inherited, or de novo--as well as loss-of-heterozygosity in cancer cells. The...

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PMID: 19570852
DOI: 10.1093/nar/gkp552
PMCID: PMC2715261

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