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Article

Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.

Human molecular genetics - 15 Jun 2011

Reis Surya A, Thompson Morgan N, Lee Jong-Min, Fossale Elisa, Kim Hyung-Hwan, Liao James K, Moskowitz Michael A, Shaw Stanley Y, Dong Linda, Haggarty Stephen J, MacDonald Marcy E, Seong Ihn Sik

Abstract excerpt

The expanded CAG repeat that causes striatal cell vulnerability in Huntington's disease (HD) encodes a polyglutamine tract in full-length huntingtin that is correlated with cellular [ATP] and [ATP/ADP]. Since striatal neurons are vulnerable to energy deficit, we have investigated, in Hdh CAG knock-in mice and striatal cells, the hypothesis that decreased energetics may affect neuronal (N)-cadherin, a candidate...

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Identifiers

PMID: 21447599
DOI: 10.1093/hmg/ddr127
PMCID: PMC3098733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Striatal neurons expressing full-length mutant huntingtin exhibit decreased N-cadherin and altered neuritogenesis.PMID 21447599Read ↗

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