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Article

Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences.

The Journal of biological chemistry - 17 Nov 2006

Milakovic Tamara, Quintanilla Rodrigo A, Johnson Gail V W

Abstract excerpt

Huntington disease (HD) is caused by a pathological elongation of CAG repeats in the huntingtin protein gene and is characterized by atrophy and neuronal loss primarily in the striatum. Mitochondrial dysfunction and impaired Ca2+ homeostasis in HD have been suggested previously. Here, we elucidate the effects of Ca2+ on mitochondria from the wild type (STHdhQ7/Q7) and mutant (STHdhQ111/Q111) huntingtin-expressing...

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Identifiers

PMID: 16973623
DOI: 10.1074/jbc.M603845200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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