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Article

Genotoxicity of mesoporous silica nanoparticles in human embryonic kidney 293 cells.

Drug testing and analysis - 1 Sept 2015

Zhang Quanan, Xu Hanfeng, Zheng Shengqin, Su Mu, Wang Jiandong

Abstract excerpt

Mesoporous silica nanoparticles (MSNs) have been widely evaluated for their potential use as carriers for cancer diagnosis and therapy. Understanding the toxicity of MSNs is crucial to their biomedical applications. Although several groups have reported the cytotoxicity of MSNs, the genotoxicity (inducing genetic aberrations) of MSNs in normal human cells has not been extensively investigated. Gene amplification...

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Identifiers

PMID: 25583601
DOI: 10.1002/dta.1773

Genes

KRAS
EGFR
MSN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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