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Article

Prion protein polymorphisms affect chronic wasting disease progression.

PloS one - 18 Mar 2011

Johnson Chad J, Herbst Allen, Duque-Velasquez Camilo, Vanderloo Joshua P, Bochsler Phil, Chappell Rick, McKenzie Debbie

Abstract excerpt

Analysis of the PRNP gene in cervids naturally infected with chronic wasting disease (CWD) suggested that PRNP polymorphisms affect the susceptibility of deer to infection. To test this effect, we orally inoculated 12 white-tailed deer with CWD agent. Three different PRNP alleles, wild-type (wt; glutamine at amino acid 95 and glycine at 96), Q95H (glutamine to histidine at amino acid position 95) and G96S...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21445256
DOI: 10.1371/journal.pone.0017450
PMCID: PMC3060816

Genes

PRNP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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