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Article

Isoproterenol Increases RANKL Expression in a ATF4/NFATc1-Dependent Manner in Mouse Osteoblastic Cells.

International journal of molecular sciences - 20 Oct 2017

Baek Kyunghwa, Park Hyun-Jung, Baek Jeong-Hwa, Kim Hyung-Ryong

Abstract excerpt

Sympathetic nervous system stimulation-induced β-adrenergic signal transduction is known to induce bone loss and increase of osteoclast activity. Although isoproterenol, a nonspecific β-adrenergic receptor agonist, has been shown to increase receptor activator of NF-κB ligand (RANKL), the details of the regulatory mechanisms remain unclear. In the present study, we investigated the role of the nuclear factor of...

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Source

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Identifiers

PMID: 29053621
DOI: 10.3390/ijms18102204
PMCID: PMC5666884

Genes

ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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