Close linkage of esterase-D to unipolar depression and alcoholism is ruled out in eight pedigrees.

doi:10.15288/jsa.1991.52.609

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Article

Close linkage of esterase-D to unipolar depression and alcoholism is ruled out in eight pedigrees.

Journal of studies on alcohol - 1 Nov 1991

Wesner R B, Tanna V L, Palmer P J, Thompson R J, Crowe R R, Winokur G

Abstract excerpt

Unipolar depression and alcoholism were tested for genetic linkage to esterase-D at 13q14.1. Tight linkage to esterase-D was ruled out for three phenotypes using three models of penetrance: (1) unipolar depression and alcoholism taken together as affected, (2) unipolar depression alone as affected with alcoholism considered unaffected and (3) alcoholism alone as affected with unipolar depression considered...

Topics

Adolescent
Adult
Alcoholism
Carboxylesterase
Carboxylic Ester Hydrolases
Chromosome Aberrations
Chromosome Disorders
Chromosomes, Human, Pair 13
Depressive Disorder
Female
Genes, Dominant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Linkage

Genetic Markers

Humans

Male

Middle Aged

Pedigree

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1758189
DOI: 10.15288/jsa.1991.52.609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1758189-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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