Article
Circumventing heterozygosity: sequencing the amplified genome of a single haploid Drosophila melanogaster embryo.
Genetics - 1 Jun 2011
Langley Charles H, Crepeau Marc, Cardeno Charis, Corbett-Detig Russell, Stevens Kristian
Abstract excerpt
Heterozygosity is a major challenge to efficient, high-quality genomic assembly and to the full genomic survey of polymorphism and divergence. In Drosophila melanogaster lines derived from equatorial populations are particularly resistant to inbreeding, thus imposing a major barrier to the determination and analyses of genomic variation in natural populations of this model organism. Here we present a simple...
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