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Article

Detecting heterozygosity in shotgun genome assemblies: Lessons from obligately outcrossing nematodes.

Genome research - 1 Mar 2009

Barrière Antoine, Yang Shiaw-Pyng, Pekarek Elizabeth, Thomas Cristel G, Haag Eric S, Ruvinsky Ilya

Abstract excerpt

The majority of nematodes are gonochoristic (dioecious) with distinct male and female sexes, but the best-studied species, Caenorhabditis elegans, is a self-fertile hermaphrodite. The sequencing of the genomes of C. elegans and a second hermaphrodite, C. briggsae, was facilitated in part by the low amount of natural heterozygosity, which typifies selfing species. Ongoing genome projects for gonochoristic...

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PMID: 19204328
DOI: 10.1101/gr.081851.108
PMCID: PMC2661809

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