Article
Development of a screening protocol to identify persons who are responsive to wood smoke particle-induced airway inflammation with pilot assessment of GSTM1 genotype and asthma status as response modifiers.
Inhalation toxicology - 1 Jan 2022
Alexis Neil E, Zhou Laura Y, Burbank Allison J, Almond Martha, Hernandez Michelle L, Mills Katherine H, Noah Terry L, Wells Heather, Zhou Haibo, Peden David B
Abstract excerpt
BACKGROUND: We are currently screening human volunteers to determine their sputum polymorphonuclear neutrophil (PMN) response 6- and 24-hours following initiation of exposure to wood smoke particles (WSP). Inflammatory responders (≥10% increase in %PMN) are identified for their subsequent participation in mitigation studies against WSP-induced airways inflammation. In this report we compared responder status...
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